LT Trent Williams, WR Ricky Pearsall will not practice Wednesday

The San Francisco 49ers are facing uncertainty regarding the availability of key players ahead of their wild-card game against the Philadelphia Eagles. Left tackle Trent Williams, who injured his hamstring in Week 17 against the Bears, will not practice on Wednesday, as confirmed by head coach Kyle Shanahan. Williams' absence was felt in the Week 18 loss to the Seahawks, which forced the 49ers into the wild-card round.

In addition to Williams, wide receiver Ricky Pearsall, dealing with knee and ankle injuries, will also miss Wednesday's practice after aggravating his PCL injury against the Bears. Linebacker Dee Winters and defensive end Keion White are sidelined with ankle and groin/hamstring injuries, respectively.

Tight end George Kittle, defensive end Yetur Gross-Matos, and linebacker Luke Gifford are expected to be limited participants in practice due to their respective injuries. The 49ers are preparing to face the Eagles without the benefit of a first-round