Buffalo vs Minnesota Prediction, Picks & Odds for August 28 — College Football Week 1

The Buffalo Bulls are set to face the Minnesota Golden Gophers on Thursday, August 28, 2025, at Huntington Bank Stadium in Minneapolis, MN, with kickoff at 8:00 p.m. ET on Fox Sports. Buffalo, under head coach Pete Lembo, returns 10 defensive starters and is expected to present a challenge for Minnesota's new starting quarterback, Drake Lindsey. The Golden Gophers, led by head coach P.J. Fleck, are expected to rely on their running backs, Darius Taylor and AJ Turner, due to uncertainties surrounding their offensive line, which lost three starters from last season. Minnesota is favored by 17.5 points, but Buffalo's disciplined defense could keep the game close. Historically, Minnesota has struggled against the spread in season openers under Fleck, with a 2-5-1 record. The betting odds list Buffalo at +740 on the moneyline, while Minnesota is at -1250, with the over/under