College football odds, picks, predictions for Week 1, 2025: Proven computer backs Alabama in best bets
Our Summary
The 2025 college football season kicks off over Labor Day Weekend, featuring games from Thursday through Monday. Highlighting Week 1 are three top-10 matchups: Texas vs. Ohio State, LSU vs. Clemson, and Notre Dame vs. Miami. Texas is facing a slight disadvantage with Ohio State favored by 2.5 points. Clemson is favored by 3.5 points against LSU, while Notre Dame is favored by 2.5 against Miami.
Other notable point spreads include No. 2 Penn State as 44.5-point favorites over Nevada and No. 5 Georgia favored by 39.5 points over Marshall. Alabama, ranked No. 8, is predicted to have a strong start, favored by 13.5 points over Florida State, a team coming off a poor 2-10 season. Meanwhile, UCLA is expected to cover a 6.5-point spread against Utah, benefiting from the addition of former Tennessee quarterback Nico Iamaleava
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