Ohio State vs. Michigan score prediction by expert football model

The highly anticipated 2025 college football rivalry game between Ohio State and Michigan is set to take place at the Big House, with significant playoff implications on the line. Ohio State enters the game aiming to secure the No. 1 overall seed in the College Football Playoff, while Michigan seeks its fifth consecutive victory in the series and a boost to its playoff prospects.

The SP+ computer prediction model forecasts a decisive win for Ohio State, predicting a 31-17 victory over Michigan, with a 14.6-point margin. The model assigns the Buckeyes an 82 percent chance of winning. Ohio State is favored by 10.5 points according to FanDuel Sportsbook, with a total points line set at 43.5. The moneyline odds are -390 for Ohio State and +310 for Michigan.

Despite Ohio State's favored status, the history of upsets in this rivalry, including Michigan's surprising win last year, adds intrigue to the matchup. The Buckeyes'