PFT's 2025 NFL wild-card weekend picks: Florio vs. Simms

The NFL wild-card weekend is set with several key matchups. The Rams are favored by 10.5 points against the Panthers, with predictions favoring the Rams to win. The Packers, slightly trailing by 1.5 points, face the Bears, with both predictions favoring a Bears victory. The Bills, also trailing by 1.5 points, will meet the Jaguars, with expectations leaning towards a Jaguars win, which could prompt discussions about potential changes for the Bills. The Eagles, with a 4.5-point advantage, are favored to defeat the 49ers, despite early playoff meetings. The Patriots, holding a 3.5-point edge, are predicted to overcome the Chargers, marking a potential end to their playoff drought since Super Bowl LIII. Lastly, the Texans, favored by 3 points, will face the Steelers, with predictions split on the outcome. These matchups are crucial as teams vie for advancement in the playoffs.